Sunday, July 10, 2011

External Fixation Pins & Nitric Oxide

As with every month, there are a plethora of journals for us here at FootandAnkleFixation.com to scour through and we try to pull out the most interesting and pertinent articles that pertain to foot and ankle surgery and fixation. Some months there is a paucity of literature that is relevant to our interest and in others there is an abundance that we will pour over into the Daily Fix. And in our readings for this month comes a few interesting articles that we didn't want to leave out. So without further ado....

Researchers at the University of North Carolina School of Medicine, Chapel Hill, NC and in conjunction with the Department of Orthopaedics, and Department of Chemistry have published a paper in the Journal of Orthopaedic Trauma on the antibacterial activity of nitric oxide (NO)-releasing xerogel on titanium pins used as external fixation in rat models. They found that in comparison to a control group and xerogel without nitric oxide, the group of rats that had the nitric oxide (NO)-releasing xerogel demonstrated significantly lower counts of pin tract bacterial colony counts and fewer clinical signs of infection. In the end they concluded the following:

"The application of NO-releasing xerogel coatings can inhibit bacterial colonization of external fixation pins both during the initial postsurgical period and up to 48 days postimplantation."

For those of you interested in reading further about their findings, you can purchase the entire article here from The Journal of Orthopaedic Trauma.

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